Structural Genomics Consortium - a non-profit organization focusing on structural biology of proteins relevant to human health

The SGC works with a list of protein targets approved by our Scientific Committee. From time to time, we decrease or stop efforts on specific targets for reasons including

The structure has been solved by a non-SGC party.
Our best efforts have failed to yield soluble protein, diffracting crystals or a structural solution meeting our quality criteria.
We have made a strategic decision to focus on other targets.

Here we present a list of these de-prioritized targets, sortable by clicking on the column headings. Where available, click on the embedded link in each target ID to show the related experimental details, including methods attempted and results obtained. The details may enable others to reproduce and possibly improve on our results. The results presented represent preliminary observations that have not been fully verified. In specific cases, reagents may be made available to enable third party experiments.

Protein Family	Target ID	Public database accession	Description	Status	Experimental data link	Reagent available?
Oxidoreductases	ACAD8	gi\|7656849	Human acyl-coenzyme A dehydrogenase family, member 8	A structure of this target was deposited in the PDB by another laboratory	Available	No
Protein Kinases	ACK1	gi\|8922075	Human ACK1: activated Cdc42-associated kinase 1	A structure of this target was deposited in the PDB by another laboratory	N/A	No
Protein Kinases	ADCK4	gi\|27363457	Human aarF domain containing kinase 4	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	ADRBK1	gi\|4501971	Human adrenergic, beta, receptor kinase 1	A structure of this target was deposited in the PDB by another laboratory	N/A	No
Protein Kinases	AKAP11	gi\|7706457	Human A kinase (PRKA) anchor protein 11 [isoform 1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	AKAP12	gi\|21493022	Human A kinase (PRKA) anchor protein (gravin) 12 [isoform 1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	AKAP2	gi\|6005709	Human A kinase (PRKA) anchor protein 2 [isoform 1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	AKAP4	gi\|21493037	Human A kinase (PRKA) anchor protein 4 [isoform 1]	This target is of low-priority for strategic reasons	Available	No
Protein Kinases	AKAP5	gi\|21493043	Human A kinase (PRKA) anchor protein 5	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	AKAP6	gi\|21493045	Human A kinase (PRKA) anchor protein 6	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	AKAP8	gi\|5031579	Human A kinase (PRKA) anchor protein 8	This target is of low-priority for strategic reasons	N/A	No
Protein Kinases	AKAP9	gi\|22538391	Human A kinase (PRKA) anchor protein (yotiao) 9 [isoform 1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Oxidoreductases	AKR1B10	gi\|20127592	Human aldo-keto reductase family 1, member B10 (aldose reductase)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	AKR1C3	gi\|24497583	Human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	AMID	gi\|14318424	Human AMID: apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
GTPases	CBPP22	gi\|6005731	Human CHP: calcium binding protein P22	A structure of this target was deposited in the PDB by another laboratory	Available	No
Cyclins	CCNE1	gi\|17318559	Human cyclin E1 [isoform 1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Cyclins	CCNE2	gi\|17318565	Human cyclin E2 [isoform 1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Cyclins	CCNI	gi\|5802992	Human cyclin I	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Cyclins	CCNL1	gi\|9945320	Human cyclin L1	A structure of this target was deposited in the PDB by another laboratory	Available	No
Methyltransferases	COMT	NP_000745	catechol-O-methyltransferase	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	Yes
Oxidoreductases	CRYZL1	gi\|14577925	Human crystallin, zeta (quinone reductase)-like 1 [isoform a; tv1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	CSNK1D	gi\|20149530	Human casein kinase 1, delta [isoform 1]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Protein Kinases	CSNK1E	gi\|23199991	Human casein kinase 1, epsilon [isoform 1; tv1]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	CTDSP1	gi\|10864009	Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 [isoform 1]	A structure of this target was deposited in the PDB by another laboratory	N/A	No
Oxidoreductases	CYB5	gi\|4503183	Human cytochrome b-5 [isoform 1]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Sulfotransferases	D4ST1	NP_569735	D4ST-1: dermatan-4-sulfotransferase-1	This target is of low-priority for strategic reasons	Available	Yes
Oxidoreductases	DCXR	gi\|7705925	Human dicarbonyl/L-xylulose reductase	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	DECR1	gi\|4503301	Human 2,4-dienoyl CoA reductase 1, mitochondrial	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	DHRS6L	gi\|14754051	Similar to Human oxidoreductase UCPA	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	DLD	gi\|4557525	Human dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	DUSP10	gi\|6005812	Human dual specificity phosphatase 10 [isoform a; tv1]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	DUSP15	gi\|29826315	Human dual specificity phosphatase-like 15 [isoform a]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	DUSP18	gi\|51093845	Human dual specificity phosphatase 18	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	DUSP3	gi\|4758208	Human dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	DUSP9	gi\|4503421	Human dual specificity phosphatase 9	A structure of this target was deposited in the PDB by another laboratory	Available	No
Membrane proteins	ECCORB4	gi\|16129770	yoaE - putative transport protein [Escherichia coli K12]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Membrane proteins	ECEAAT2	gi\|16131400	dctA - citrate and C4-dicarboxylic acids transport protein (DAACS family) [Escherichia coli K12]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	ECNACA1	gi\|16131086	yrbG - putative Na:Ca transport protein (CacA family) [Escherichia coli K12]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	ECNAPI2	gi\|16131019	garP - putative transport protein [Escherichia coli K12]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	ECNRAMP1	gi\|16130324	mntH - manganese/divalent cation transport protein (NRAMP family) [Escherichia coli K12]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	ECTRKG1	gi\|16129324	trkG - Trk system potassium uptake [Escherichia coli K12]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	ECZN2	gi\|16131753	yiiP - putative transport protein (CDF family) [Escherichia coli K12]	This target is of low-priority for strategic reasons	Available	No
Oxidoreductases	ECZNTA1	gi\|16127996	bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal)	This target is of low-priority for strategic reasons	Available	No
Nuclear Receptors	ESRRB	NP_004443	estrogen-related receptor beta	This target is of low-priority for strategic reasons	Available	Yes
Phosphatases	EYA2	gi\|26667230	Human eyes absent 2 [isoform c; tv5]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Phosphatases	EYA4	gi\|26667252	Human eyes absent 4 [isoform b]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Kinases	FYN	gi\|4503823	Human FYN oncogene related to SRC, FGR, YES [isoform a]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	GCDH	gi\|4503943	Human glutaryl-Coenzyme A dehydrogenase [isoform a]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	GPD1	gi\|33695088	Human glycerol-3-phosphate dehydrogenase 1 (soluble)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	H6PD	gi\|4758498	Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Oxidoreductases	HADHA	gi\|20127408	Human hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Miscellaneous	HMGCL	gi\|4504427	Human 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)	A structure of this target was deposited in the PDB by another laboratory	Available	No
PDZ linkers	HOMER1	gi\|4759198	Human homer homolog 1 (Drosophila)	A structure of this target was deposited in the PDB by another laboratory	N/A	No
PDZ linkers	HOMER2	gi\|46249349	Human homer homolog 2 (Drosophila) [isoform 1]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	IDH1	gi\|28178825	Human isocitrate dehydrogenase 1 (NADP+), soluble	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	IFI30	gi\|29150261	Human interferon, gamma-inducible protein 30	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Oxidoreductases	INSIG1	gi\|28882053	Human insulin induced gene 1 [isoform 1]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Miscellaneous	LSS	gi\|31377811	Human lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Malaria	MAL13P1.505	MAL13P1.505	STEVOR	This target is of low-priority for strategic reasons	Available	Yes
Malaria	MAL6P1.215	MAL6P1.215	pyridoxine biosynthetic enzyme pdx1 homologue, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	MAL6P1.40	MAL6P1.40	phenylalanine -- tRNA ligase, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	MAL7P1.150	MAL7P1.150	cysteine desulfurase, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	MAL7P1.161	MAL7P1.161	dynein light chain, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	MAL7P1.20	MAL7P1.20	peptide chain release factor	This target is of low-priority for strategic reasons	Available	Yes
Protein Kinases	MAP2K1	gi\|5579478	Human mitogen-activated protein kinase kinase 1	A structure of this target was deposited in the PDB by another laboratory	N/A	No
Protein Kinases	MAPK9	gi\|21237736	Human mitogen-activated protein kinase 9 [isoform 1]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Oxidoreductases	MDH1	gi\|5174539	Human malate dehydrogenase 1, NAD (soluble)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Membrane proteins	MMNASI4	gi\|23016229	Magn0210675 - COG0659: Sulfate permease and related transporters (MFS superfamily) [Magnetospirillum magnetotacticum]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Membrane proteins	MMNHE5	gi\|46201320	Magn029948 - COG3263: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Magnetospirillum magnetotacticum]	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Nuclear Receptors	NCO5A	gi\|15147335	Human nuclear receptor coactivator 5	This target is of low-priority for strategic reasons	Available	No
Sulfotransferases	NDST2	NP_003626	N-deacetylase-N-sulfotransferase (heparan glucosaminyl) 2	This target is of low-priority for strategic reasons	Available	Yes
Sulfotransferases	NDST4	NP_072091	N-deacetylase-N-sulfotransferase 4	This target is of low-priority for strategic reasons	Available	Yes
Membrane proteins	NPCLC1	gi\|23124328	Npun0699 - COG0038: Chloride channel protein EriC [Nostoc punctiforme]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	NPCLC2	gi\|23125572	Npun1898 - COG0517: FOG: CBS domain [Nostoc punctiforme]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	NPCLC3	gi\|23125776	Npun2099 - COG0517: FOG: CBS domain [Nostoc punctiforme]	This target is of low-priority for strategic reasons	Available	No
Membrane proteins	NPCLC4	gi\|23130296	Npun6598 - COG0517: FOG: CBS domain [Nostoc punctiforme]	This target is of low-priority for strategic reasons	Available	No
nuclear receptor	NR2E3	NP_055064	nuclear receptor subfamily 2, group E, member 3	This target is of low-priority for strategic reasons	Available	Yes
nuclear receptor	NR2F1	NP_005645	nuclear receptor subfamily 2, group F, member 1	This target is of low-priority for strategic reasons	Available	Yes
nuclear receptor	NR4A3	NP_008912	nuclear receptor subfamily 4, group A, member 3	This target is of low-priority for strategic reasons	Available	Yes
Oxidoreductases	OGDH	gi\|4505493	Human oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Miscellaneous	PC	gi\|4505627	Human pyruvate carboxylase [isoform 1; tv1]	This target is of low-priority for strategic reasons	Available	No
Oxidoreductases	PDHA2	gi\|4885543	Human pyruvate dehydrogenase (lipoamide) alpha 2	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Oxidoreductases	PDHX	gi\|4505699	Human pyruvate dehydrogenase complex, component X	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Malaria	PF07_0130	PF07_0130	stevor	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF11_0516	PF11_0516	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF13_0180	PF13_0180	chaperonin, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF13_0350	PF13_0350	(protein coding) signal recognition particle receptor alpha subunit, putative Location= chr13 complement(2659757..2661487)	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF14_0007	PF14_0007	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF14_0148	PF14_0148	uracil-DNA glycosylase, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF14_0256	PF14_0256	exosome complex exonuclease rrp41, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF14_0477	PF14_0477	signal recognition particle 54 kDa protein, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF14_0767	PF14_0767	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PF14_0771	PF14_0771	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFA0090c	PFA0090c	stevor	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFA0750w	PFA0750w	stevor	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFB0025c	PFB0025c	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFB0050c	PFB0050c	stevor isoform gam beta	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFB0065w	PFB0065w	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFB0215c	PFB0215c	3'-5' exonuclease, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFB1020w	PFB1020w	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFC0025c	PFC0025c	stevor, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFC0155c	PFC0155c	DNA-directed RNA polymerase subunit I, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFC0340w	PFC0340w	DNA polymerase delta small subunit, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFC1105w	PFC1105w	stevor (3D7-stevorT3-2)	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFD0035c	PFD0035c	stevor	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFF0625w	PFF0625w	(protein coding) nucleolar GTP-binding protein 1, putative Location= chr6 531121..533181	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFI0080w	PFI0080w	stevor	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFI0215c	PFI0215c	signal peptidase, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFI0385c	PFI0385c	S1-P1nuclease, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFI0525w	PFI0525w	nucleotide binding protein, putative	This target is of low-priority for strategic reasons	Available	Yes
Malaria	PFL2510w	PFL2510w	Chitinase	This target is of low-priority for strategic reasons	Available	Yes
Membrane proteins	PLAUR	gi\|4505865	Human Urokinase plasminogen activator surface receptor precursor (uPAR) (U-PAR) (Monocyte activation antigen Mo3) (CD87 antigen)	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	PPP1R14A	gi\|15147250	Human protein phosphatase 1, regulatory (inhibitor) subunit 14A	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Phosphatases	PPP1R14B	gi\|37540993	Human protein phosphatase 1, regulatory (inhibitor) subunit 14B	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Phosphatases	PPP1R14C	gi\|19311006	Human protein phosphatase 1, regulatory (inhibitor) subunit 14C	This target has been extensively pursued but due to resource constraints, is not currently of high priority	Available	No
Protein Kinases	PRKACB	gi\|4506057	Human protein kinase, cAMP-dependent, catalytic, beta [isoform b]	A structure of this target was deposited in the PDB by another laboratory	Available	No
Protein Kinases	PRKCB1	gi\|20127450	Human protein kinase C, beta 1	A structure of this target was deposited in the PDB by another laboratory	Available	No
Protein Kinases	PRKCI	gi\|31543439	Human protein kinase C, iota	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	PTPRN	gi\|4506321	Human protein tyrosine phosphatase, receptor type, N	A structure of this target was deposited in the PDB by another laboratory	Available	No
Phosphatases	PTPRS	gi\|19743919	Human protein tyrosine phosphatase, receptor type, S [isoform 1 precursor]	A structure of this target was deposited in the PDB by another laboratory	Available	No
GTPases	RAP1A	gi\|4506413	Human RAP1A, member of RAS oncogene family	A structure of this target was deposited in the PDB by another laboratory	N/A	No
GTPases	RAP1B	gi\|7661678	Human RAP1B, member of RAS oncogene family	A structure of this target was deposited in the PDB by another laboratory	N/A	No
GTP