Publications in Print

Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH. L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol. 12):1229-30. (2008)
Weigelt J, McBroom-Cerajewski LD, Schapira M, Zhao Y, Arrowmsmith CH. Structural Genomics and Drug Discovery: All in the Family Curr Opin Chem Biol NULL (2008)
Stenmark P, Kursula P, Flodin S, Gräslund S, Landry R, Nordlund P, Schüler H. Crystal structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the ITPA Deficiency Mutation P32T Journal of Biological Chemistry 282(5):3182-7 (2008)
Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Human HDAC7 harbors a class IIa HDAC-specific zinc binding motif and cryptic deacetylase activity. J Biol. Chem NULL (2008)
Hozjan V, Guo K, Wu X, Oppermann U. Ligand supplementation as method to increase soluble heterologous protein production Exp Rev Proteomics 5(1):137-43. (2008)
Ludwig C, Michiels PJ, Wu X, Kavanagh KL, Pilka E, Jansson A, Oppermann U, Günther UL. SALMON: Solvent accessibility, ligand binding and mapping of ligand orientation by NMR spectroscopy. J. Med Chem 51(1):1-3 (2008)
Eswaran J, Bernad A, Ligos JM, Guinea B, Debreczeni JE, Sobott F, Parker SA, Najmanovich R, Turk BE, Knapp S. Structure of the human protein Kinase STK16 Reveals a Novel Activation Loop Architecture Structure 16(1):115-24 (2007)
Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S. Systematic analysis of inhibitor binding profiles to Ser/Thr kinases. PNAS 104(51):20523-8 (2007)
Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. Evaluation of Micro-Parallel Liquid Chromatography (PLC) as a Method for HTS-coupled Actives Verification. Drug Development Technologies 5(6):815-24. (2007)
Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+). PLoS Biol. 5(10):e263 (2007)
Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH. Human holo-ACP synthase: structure, mechanism and substrate recognition Chemistry and Biology 14(11):1243-53 (2007)
Bullock AN, Rodriguez MC, Debreczeni JE, Songyang Z, Knapp S. Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation. Structure 15(11):1493-504 (2007)
Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH. Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci. 1117:209-57. (2007)
Dong A, Xu X, Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H. In Situ Proteolysis for Protein Crystallization and Structure Determination. Nature Methods 4(12):1019-21 (2007)
Krajewski W, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T,and Mowbray S Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes, and provide opportunities for drug and herbicide design. J. Mol. Biol. 375(1):217-28. (2007)
Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, Muller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S. Structural and Functional Characterization of the Human Protein Kinase ASK1. Structure (10):1215-26. (2007)
Gileadi O, Knapp S, Lee WH, Marsden BD, Muller S, Niesen FH, Kavanagh KL, Ball LJ, von Delft F, Doyle DA, Oppermann UC, Sundstrom M. The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins J Struct Funct Genomics 15(10):1215-26 (2007)
Niesen FH, Berglund H, Vedadi M. The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat. Protocol 2(9):2212-21. (2007)
Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN. Structure and Mechanism of Spermidine Synthases. Biochemistry 46(28):8331-8339 (2007)
Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J Biol Chem. 282(38):27984-93 (2007)
Anthony O., Knapp S, Pearl L. T-loop exchange: A common mechanism of kinase activation. TIBS. 32(8):351-6 (2007)
Pogacic V, Bullock AN, Fedorov O, Filippakopoulos P, Gasser C, Biondi A, Meyer-Monard S, Knapp S, and Schwaller J Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity Cancer Research 67: 6916-6924 (2007)
Högbom M, Collins R, van den Berg S, Jenvert RM, Karlberg T, Kotenyova T, Flores A, Hedestam GB, Schiavone LH. Crystal Structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP J Mol Biol 372(1):150-9 (2007)
Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Crystal Structures of Histone Demethylase JMJD2A Reveal Basis for Substrate Specificity. Nature 448(7149):87-91 (2007)
Walldén K, Stenmark P, Nyman T, Flodin S, Gräslund S, Loppnau P, Bianchi V and Nordlund P. Crystal Structure of Human Cytosolic 5'-Nucleotidase: Insights into Allosteric Regulation and Substrate Recognition J Biol Chem 282(24):17828-36 (2007)
Walldén K, Stenmark P, Nyman T, Flodin S, Gräslund S, Loppnau P, Bianchi V and Nordlund P. Crystal Structure of Human Cytosolic 5'-Nucleotidase: Insights into Allosteric Regulation and Substrate Recognition J Biol Chem 282(24):17828-36 (2007)
Sundqvist G, Stenvall M, Berglund H, Ottosson J, Brumer H. A General, Robust Method for the Quality Control of Intact Proteins using LC-ESI-MS J Chromatogr B Analyt Technol Biomed Life Sci. 852(1-2):188-94 (2007)
Allai-Hassani A, Pan W, Dombrovski L, Nojmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thorton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases PLoS Biology 5(6):e165 (2007)
Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD. Structures of the Human eIF4E Homologous Protein, h4EHP in its m7GTP-bound and Unliganded forms J. Mol. Biol. 368(3):691-705 (2007)
Fedorov O, Sundström M, Marsden BD and Knapp S. Insights for the Development of Specific Kinase Inhibitors by Targeted Structural Genomics. Drug Discovery Today 12(9-10): 365-72 (2007)
Schuetz A, Bernstein G, Dong A, Antoshenko T, Wu H, Loppnau P, Bochkarev A, Plotnikov AN. Crystal Structure of a Binary Complex Between Human GCN5 Histone Acetyltransferase Domain and Acetyl Coenzyme A Proteins: structure, function and bioinformatics 68(1):403-7 (2007)
Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X. Structural basis of allele variation of human thiopurine-S-methyltransferase Proteins 67(1):198-208 (2007)
Baminger B, Ludwiczek ML, Kontaxis G, Knapp S, Konrat R. Protein-protein interaction site mapping using NMR-detected mutational scanning. J Biomol NMR. 38(2):133-7 (2007)
Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Lee WH, Adamski J, Oppermann U, Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity Biochem J 402(3):419-27 (2007)
Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP. A Potent, Covalent Inhibitor of Orotidine 5'-Monophosphate Decarboxylase with Antimalarial Activity J Med Chem. 50(5): 915-921 (2007)
Wu X, Knapp S, Stamp A, Stammers DK, Jornvall H, Dellaporta SL, Oppermann U. Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities. FEBS 274(5):1172-82 (2007)
Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Federov O, Shen QY, Fry AM, Knapp S, Smerdon SJ. Structure and regulation of the human NEK2 centrosomal kinase. J Biol Chem. 282(9):6833-6842 (2007)
Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN. Structural Basis of Inhibition of the Human NAD(+)-Dependent Deacetylase SIRT5 by Suramin. Structure. 15(3):377-89 (2007)
Wu X , Lukacik P, Kavanagh KL, Oppermann U SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation. Mol Cell Endocrinol 265-266:71-6 (2007)
Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR and Knapp S. Crystal structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure 201-13 (2007)
Davis TL, Walker JR, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J Mol Biol 366(1):216-29 (2007)
Stenmark P, Kursula P, Flodin S, Graslund S, Landry R, Nordlund P, Schuler H. Crystal structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the ITPA Deficiency Mutation P32T Journal of Biological Chemistry 282(5):3182-7 (2007)
Johansson C , Kavanagh KL, Gileadi O , Oppermann U Reversible Sequestration of Active Site cysteines in a 2Fe2S-bridged dimer provides a mechanism for mitochondrial glutaredoxin regulation. J Biol Chem 282(5):3077-82 (2007)
Soundararajan M, Yang X, Elkins JM, Sobott F and Doyle DA The Centaurin Gamma-1 GTPase-like domain functions as an NTPase. Biochem J. 401(3):679-88 (2007)
Wu H,  Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau  P, Vedadi M, Bochkarev A, Plotnikov AN and Cheng X. Structural Basis of Allele Variation of Human Thiopurine-S-Methyltransferase. Proteins: Structure, Function, and Bioinformatics. 67(1):198-208 (2007)
Stenmark P, Ogg D, Flodin S, Flores A, Kotenyova T, Nyman T, Nordlund P, Kursula P. The structure of human collapsin response mediator protein 2, a regulator of axonal growth Journal of Neurochemistry. 101(4):906-917 (2007)
Najmanovich RJ, Allali-Hassani A, Morris RJ, Dombrovski L, Pan PW, Vedadi M, Plotnikov AN, Arrowsmith C, Edwards AM and Thornton JM Analysis of binding site similarity, small molecule similarity and experimental binding profiles in the human cytosolic. ECCB 23(2):e104-9 (2007)
Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R. Genome-Scale Protein Expression and Structural Biology of Plasmodium falciparum and Related Apicomplexan Organisms. Molecular and Biochemical Parasitology. 151(1):100-10 (2007)
Gileadi O, Burgess-Brown NA, Colebrook SM, Berridge G, Savitsky P, Smee CEA, Loppnau P, Johansson C, Salah E, and Pantic, N. High Throughput Production of Recombinant Human Proteins for Crystallography. Methods in Molecular Biology, vol. 426 (B. Kobe, M. Guss and T. Huber, eds.) pp 221- 46. (2007)
Fedorov OY, Higman VA, Schmieder P, Leidert M, Diehl A, Elkins J, Soundararajan M, Oschkinat H, Ball LJ. Resonance Assignment of the RGS Domain of Human RGS10 Journal of Biomolecular NMR. 38(2):191 (2006)
Senisterra GA, Markin E, Yamazaki K, Hui R, Vedadi M, Awrey DE. Screening for Ligands using a Generic and High-throughput Light-scattering-based Assay. J Biomol Screen 11(8):940-8 (2006)
Avvakumov GV, Walker JR, Xue S, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S. Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). J Biol Chem 281(49):38061-70 (2006)
Yang, X., Lee, W.H., Sobott, F., Papagrigoriou, E, Robinson, C.V., Grossmann, J.G., Sundstrom, M., Doyle, D.A., Elkins, J.M. (2006). Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc. Natl. Acad. Sci. USA 103(46):17237-42 (2006)
Busam RD, Thorsell A-G, Flores A, Hammarström M, Persson C, and Hallberg BM First Structure of a Eukaryotic Phosphohistidine Phosphatase J Biol Chem 281(45):33830-4 (2006)
Littler DR, Walker JR, She YM, Finerty PJ Jr, Newman EM, Dhe-Paganon S. Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites. BBRC 349(4):1182-9 (2006)
Barr AJ, Knapp S MAPK-specific tyrosine Phosphatases: New Targets for Drug Discovery? TIPS 27(10):525-30 (2006)
Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ Jr, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM. Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. PNAS 103(43):15835-4 (2006)
Kursula P, Schuler H, Flodin S, Nilsson-Ehle P, Ogg DJ, Savitsky P, Nordlund P, Stenmark P. Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue. Acta Crystallogr D Biol Crystallogr. 62(Pt 11):1294-9 (2006)
Kursula P, Schuler H, Flodin S, Nilsson-Ehle P, Ogg DJ, Savitsky P, Nordlund P, Stenmark P. Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue. Acta Crystallogr D Biol Crystallogr. 62(Pt 11):1294-9 (2006)
Yee A, Gutmanas A and Arrowsmith CH. NMR in Structural Genomics Curr Opin Stuct Biol. 16(5):611-7 (2006)
Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH and Min JR. Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO 25(18):4245-52 (2006)
Dombrovski L, Dong A, Bochkarev A, Plotnikov AN. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). PROTEINS: Structure, Function, and Bioinformatics. 64(4):1091-4 (2006)
Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW and Leonardi R. Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties. Structure 14(8):1251-61 (2006)
Magnusdottir A, Stenmark P, Flodin S, Nyman T, Hammarstrom M, Ehn M, Bakali H MA, Berglund H, Nordlund P. The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. J Biol Chem 281(32):22434-8 (2006)
Kavanagh KL, Dunford JE, Bunkoczi G, Russell GG and Oppermann U. The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. J Biol Chem 281(31):22004-1 (2006)
Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P. Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy Acta Crystallograph Sect F Struct Biol Cryst Commun 62(7):613-7 (2006)
Marsden BD, Sundstrom M and Knapp S. High Throughput Structural Characterization of Therapeutic Protein Targets. Expert Opinion in Drug Discovery (EODD) 1(2): 123-136 (2006)
Eswaran J, Debreczeni J.E, Longman E, Barr AJ and Knapp S The crystal structure of human receptor protein tyrosine phosphatase k phosphatase domain 1. Protein Science 15(6):1500-5 (2006)
Barr A.J, Debreczeni J.E, Eswaran J and Knapp S Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution. Proteins 63(4):1132-6 (2006)
Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell GG and Oppermann U. The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Anti-Osteoporosis Drugs: crystal structure and inhibition of human farnesyl pyrophosphate synthase. PNAS 103(20):7829-34 (2006)
Bullock A.N, Debreczeni J.E, Edwards A.M, Sundström M and Knapp S Crystal Structure of the SOCS2-ElonginC-ElonginB Complex Defines a Prototypical SOCS-Box Ubiquitin Ligase. PNAS 103(20):7637-42 (2006)
Eswaran J, von Kries J.P, Marsden B, Longman E, Debreczeni J.E, Ugochukwu E, Turnbull A, Lee W.H, Knapp S, Barr A.J. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7 - a family of human MAP-kinase specific protein tyrosine phosphatases. Biochem J. 395(3): 483-91 (2006)
Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U Characterization of Human DHRS6, an Orphan SDR Enzyme: a Novel, Cytosolic Type 2 R-beta-hydroxybutyrate Dehydrogenase J Biol Chem., 281(15):10291-7 (2006)
Lunin, V.V, Dobrovetsky, E., Khutoreskaya, G., Zhang, R., Joachimiak, A., Bochkarev, A., Maguire, M.E., Edwards, A.M. and Koth C.M. Crystal Structure of the CorA Mg2+ Transporter. Nature 440(7085):833-7. (2006)
Lukacik P, Kavanagh K.L and Oppermann U Structure and function of human 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinology 248(1-2):61-71 (2006)
Debreczeni J.E, Bullock A.N, Atilla E, Bregman H, Williams D.S, Knapp S, Meggers E Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1 Angew. Chemie Intl. Ed. 45(10):1580-5. (2006)
Abagyan R, Lee WH, Raush E, Budagyan L, Totrov M, Sundstrom M and Marsden B. Disseminating structural genomics data to the public: from a data dump to an animated story. TIBS 31(2):76-8 . (2006)
Domene C, Vemparala S, Klein ML, Venien-Bryan C, Doyle DA. Role of aromatic localization in the gating process of a potassium channel. Biophys. J 90(1):L01-3 (2006)
U. Oppermann, K. Kavanagh, K. Guo, S. Ng, P. Lukacik, X. Wu, E. Dubinina, N. Shafqat, J. Bray, B. Marsden, S. Sharma, M. Vedadi, F. von Delft, M. Sundstrom SDR goes SGC: a Structural Genomics Initiative Enzymology and Molecular Biology of Carbonyl Metabolism 12. p235-242 (2006)
Park HW Structure Determination of the Motor Domain of Yeast Kinesin Kar3 by X-ray Crystallography In Methods of Molecular Biology (Walker, J.M., ed) NULL (2006)
Bullock A.N, Debreczeni J.E, Knapp S, Turk B.E Structure and Substrate Specificity of the Pim-1 Kinase J. Biol. Chem 280(50):41675-82 (2005)
McDonough M.A, Kavanagh K, Searls T, Butler D, Oppermann U and Schofield C.J Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease J. Biol. Chem 280(49) 41101-10 (2005)
Bullock A.N, Debreczeni J.E, Fedorov O.Y, Nelson A, Marsden B.D, Knapp S. Structural basis of inhibitor specificity of the human proto-oncogene proviral insertion site in Moloney Murine Leukemia Virus (PIM-1) kinase. Journal of Medicinal Chemistry 48(24):7604-14 (2005)
Ismail SA, Park HW Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase Acta Crystallogr D Biol Crystallogr 61:1508-1513 (2005)
Kuo A, Domene C, Johnson LN, Doyle DA, Venien-Bryan C. Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography. Structure 13(10):1463-1472 (2005)
Domene C, Doyle DA, Venien-Bryan C Modelling of an ion channel in its open confirmation Biophys J 89(1): L01-3 (2005)
Elkins JM, PapagrigoriouE, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P and Doyle DA Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions Protein Science 16(41): 683-94 (2005)
Oppermann U. Carbonyl Reductases: The Complex Relationships of Mammalian Carbonyl- and Quinone-Reducing Enzymes and Their Role in Physiology. Annu Rev Pharmacol Toxicol 47:293-322. (2005)
Oppermann U. Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases? Curr Drug Targets: Immune, endocrine and metabolic disorders 6, 259-269 (2005)
von Delft F Structural genomics, the practical way. European Pharmaceutical Review Issue 4. (2005)
A Edwards, J Bermann and M Sundstrom. Structural Genomics and Drug Discovery. Annual Reports in Medicinal Chemistry. Pg 349-369 (2005)
Edited by M Sundstrom, M Norin and A Edwards Structural Genomics and High Throughput Structural Biology. Published by CRC/Taylor & Francis NULL (2005)
Gulbis JM, Doyle DA Potassium channel structures: do they conform? Curr Opin Struct Biol 14: 440-6 (2004)
Doyle DA Structural changes during ion channel gating. Trends Neurosci 27(6):298-302 (2004)
Doyle DA Structural themes in ion channels. Eur Biophys J 33(3):175-9 (2004)
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