The Structural Genomics Consortium (SGC)

PRE-RELEASE COORDINATESRSS

Human arachidonate 12-lipoxygenase
PDB: 3D3L
2008-05-12
Human PDZ domain containing 1 (4th PDZ domain)
PDB: 2VSP
2008-04-30

SGC NEWSRSS

2008-05-01 - Top Neurophysiologist to lead SGC Chem Biology Effort
2008-04-06 - Small Molecule Screening Workshop at SGC Toronto - March 6-8th and July 10-12th, 2008
workshop files
2008-03-21 - Visiting Scientist Program
2008-02-19 - SGC Head Urges Open Access to Boost Drug Development

STRUCTURE OF THE MONTH

Human MER kinase domain in complex with 2-(2-hydroxyethylamino)-6- (3-chloroanilino)-9isopropylpurine

The MER tyrosine kinase, which is mutated in some forms of retinitis pigmentosum, is implicated in phagocytosis and is also a potential target for therapeutic intervention in leukaemia.

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PUBLICATION OF THE MONTH

Zinc Binding Catalytic Domain of Human Tankyrase 1 J Mol Biol. 2008 May 23; 379(1):136-45

The SGC team at the Karolinska Institute have determined the structures of many poly(ADP-ribose) polymerases (PARPs). One of the latest is Tankyrase 1. Tankyrases are implicated in many important cellular functions including telomere homeostasis and mitosis.