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The SGC and the OICR jointly host the
Symposium on Chemical Biology-Based Drug Design, Toronto, November 10th 2008
SGC Toronto has moved to its new location in MaRS as of Oct., 1st 2008:
The Structural Genomics Consortium
MaRS Centre, South Tower
101 College St., Suite 700
Toronto ON M5G 1L7
Small Molecule Screening Workshop at SGC Toronto - March 6-8th and July 10-12th, 2008 (Download workshop material)
Training Collaborative Opportunities at SGC Toronto
Small Molecule Screening Workshop at SGC Toronto - July 12-14, 2007
(Download workshop material) some testimonials from attendees of the first workshop
SGC Toronto Open House - May 2, 2007
SGC Toronto reaches initial output goal with protein associated with cancer and eye disease - March 2, 2007
SGC Hosts Symposium on Malaria and Related Protozoan Diseases - March 26, 2007
Small Molecule Screening Workshop at SGC Toronto - March 29-31, 2007
(some testimonials from attendees)
November 2, 2005 - SGC Toronto Open House
May 25, 2005 - Unique Toronto Research Partnership Solves Structures Of Malaria Proteins:
May Lead To New Drugs
Feb 4, 2005 - SGC and McLaughlin-Rotman Centre to Collaborate on
Structural Biology of Malarial Proteins
Jan, 2005 - SGC Fermentor System Wins Cool Design Contest
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The SGC Toronto scientists seek to determine the 3D structures
of human proteins of therapeutic relevance to diseases such as cancer
and diabetes metabolic disorders.
We have a particular focus on proteins involved in intracellular small molecule metabolism,
enzymes involved in the transfer of methyl, acetyl and Ubiquitin-like groups, proteases
and nucleotide triphosphatases.
We are also investigating proteins from Plasmodium falciparum (and its apicomplexan relatives)
which causes malaria.
The SGC Toronto laboratories, under the direction of
Prof. Cheryl Arrowsmith,
are housed within the Faculty of Medicine at the University of Toronto
and located in the heart of cosmopolitan Toronto.
Scientists at SGC Toronto are affiliated with several University Departments
including the Banting and Best Department of Medical Research,
the Departments of Physiology, Pharmacology, Medical Biophysics,
and Medical Genetics and Microbiology.
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| Research at SGC Toronto |
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Crystallography
The crystallography group is responsible for high-throughput structure
determination of all structures generated in Toronto
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Insulin Signalling and Diabetes
The Insulin Signalling and Diabetes group investigates proteins involved with a variety of signal
transduction mechanisms, including ubiquitylation, isomerization, and
phosphorylation in order to better understand related pathophysiologies,
including insulin resistance, obesity, and diabetes. The group also
aimes at discovering and developing treatments for these diseases
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Malaria
The Malaria team works on expressing, purifying and crystallizing protein targets from apicomplexan parasites,
including various Plasmodium species which are malarial pathogens
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Cell Signaling and Metabolism
The Cell Signalling and Metabolism group studies metabolic processes that use chemical energy derived from ATP or GTP hydrolysis.
It focuses on determining the structural basis for the actions of Ras intracellular signaling proteins,
non-protein kinases and kinesin molecular motors with envisioning the molecularly targeted development of therapeutics
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Chromatin Biology and Epigenetics
The Chromatin and Epigenetics Group aims at characterizing chromatin proteins involved in histone code "reading" and "writing"
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Biophysics
The Biophysics group characterizes proteins and focuses on developing new high throughput biophysical and biochemical characterization techniques.
By screening proteins against customized chemical libraries, the group identifies ligands that promote crystallization and improve crystal quality.
It also screens for buffer conditions that reduce protein aggregation and enable them to further concentrate problematic proteins.
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Research Informatics
The Research Informatics group uses computational chemistry approaches to interface biological and chemical spaces. Technologies deployed
include molecular modeling, virtual screening, chemical diversity analysis, drug development potential evaluation, hit explosion, chemical series optimization. The team also
develops IT solutions to manage SGC data.
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Engineering
The engineering group utilizes novel techniques and instrumentation for high throughput production and characterization
of proteins of interest to the SGC. This includes automation systems, software development for data management and analysis
as well as optimization of high throughput protein expression and screening for optimal crystallization conditions.
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Biotechnology
The Biotechnology Group delivers both research and facility support services. The group provides all the clones used for expression of human and malaria-related
proteins in prokaryotic and eukaryotic cells. Clones are produced and test expressed. This enables other SGC units to solve three-dimensional structures of human and malarial proteins
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